Saccharomyces boulardii is a non-pathogenic yeast strain that has been used for healing and deterrence of diarrhea. Saccharomyces boulardii is classified as a "probiotic," or a microorganism that when ingested may have an optimistic influence on the host's physical condition. Probiotics may use their effects on the gastrointestinal system directly, or may adapt the immune system in a larger scope. Human studies indicate Saccharomyces boulardii may avert antibiotic-associated diarrhea, Clostridium difficult diarrhea in combination with antibiotic therapy, diarrhea associated with tube feeds, and keen childhood diarrhea. Hopeful initial studies have shown that Saccharomyces boulardii may be useful in curing diarrhea connected with HIV.
The German Commission E has accepted the use of Saccharomyces boulardii lyo for symptomatic healing of acute diarrhea, prophylactic and symptomatic treatment of diarrhea during travel, treatment of diarrhea occurring while tube feeding, use as an adjuvant for chronic acne, for a dietary supplementation, and for a source of B vitamins.
How does it work?
There is good confirmation that simultaneous use of Saccharomyces boulardii with antibiotic therapy reduces the incidence of developing antibiotic-associated diarrhea (AAD) (Clostridium difficile and other). In general, optimistic results occur only when Saccharomyces boulardii is continued for many days to several weeks after the course of antibiotics is clogged. Duplication of these results should still be attempted to corroborate these findings.
Several trials suggest efficacy of Saccharomyces boulardii in the healing of diarrhea in childhood. Use of Saccharomyces boulardii may be beneficial in both the decrease of stool frequency per day and the duration of diarrhea in this age group. Evidence from one clinical trial supports development of symptoms and in patients with amebiasis treated with Saccharomyces boulardii, in addition to standard therapy. Further clinical trials are necessary before a firm suggestion can be made. To maintain strength and stability, Saccharomyces boulardii is best stored under refrigeration. However, S. boulardii is moderately heat stable and does not lose strength when left at room temperature for hours and even days.
